There are many options available to help you manage nausea and vomiting. Talk with your doctor about which one is best for you. In general, anti-nausea medicines are given to prevent the problem from occurring in the first place.

The most common form of anti-nausea medication is a combination of dexamethasone (a type of steroid) and a serotonin blocker. These blockers stop the natural substance serotonin from sending a message to the brain that triggers nausea. Serotonin blockers include dolasetron (Anzemet), granisetron (Kytril and others), ondansetron (Zofran and others), and palonosetron (Aloxi).

This combination helps prevent symptoms that occur in the first 24 hours after chemotherapy, known as acute nausea. Doctors usually recommend patients continue using this drug combination for two to three days following treatment to prevent delayed nausea. By taking medication to prevent these different types of nausea, patients can also avoid developing anticipatory nausea — the queasy feeling that can come before treatment. Sometimes, just the smells, sights, and sounds of the treatment room can trigger nausea and vomiting before a new cycle of chemotherapy has even begun.

Aprepitant (Emend) is an anti-emetic drug that can be added to the combination of dexamethasone and a serotonin blocker. Together, these drugs protect against both acute and delayed nausea and vomiting. Aprepitant, taken as a pill, works by blocking the effects of a chemical produced in the body called “substance P.” A related drug, fosaprepitant (Emend for Injection), may also prevent nausea and vomiting brought on by chemotherapy. Delivered intravenously, fosaprepitant is converted to aprepitant in the body.

If you are experiencing nausea and vomiting before or after your chemotherapy treatment, talk to your doctor or nurse so that your anti-emetic regimen can be modified to minimize the problem.